I'm starting to really take to this idea that calorie restriction is a fool-proof plan for weight loss and health. One of the pioneers of calorie restriction (CR) was Dr. Roy Walford.
He was apart of the scientific team in Biosphere 2 and wrote books such as "The 120 Year Diet", "Beyond The 120 Year Diet" and "The Anti-Aging Plan". Maybe ironically, he passed away at age 79. He had Lou Gehrig's Disease. Here he is in a 2000 interview with Alan Alda on "Scientific American Frontiers":